The biological sciences study (bio)complex living systems. Research directed at the mechanistic explanation of the "live" state truly requires a pluralist research program, i.e. BioComplexity research. The program should apply multiple intra-level and inter-level theories and methodologies. We substantiate this thesis with analysis of BioComplexity: metabolic and modular control analysis of metabolic pathways, emergence of oscillations, and the analysis of the functioning of glycolysis.

Conclusion: The present results support adequate psychometric properties in terms of factorial validity, reliability, convergent validity, and measurement invariance for the PHQ-4 in young adults in Hong Kong. The PHQ-4 demonstrated a substantial mediating role in the relationship between meaning in life and SI in the distress group. These findings support clinical relevance for using the PHQ-4 as a brief and valid measure of psychological distress in the Chinese context.

The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

This chapter describes the potential far‐reaching consequences of contemplative higher education for the fields of science and medicine.

I anledning af Judith Butlers forelæsning om klimasorg på KU er jeg blevet bedt om at besvare spørgsmålet om, hvad man kan bruge Butlers tænkning til i dag og om den stadig er aktuel. Min første tanke var at besvare spørgsmålet med svaret: Man kan bruge Butlers tænkning til ALT! Men for at fokusere mit svar, har jeg besluttet mig for at gennemgå Butlers tænkning i forhold til spørgsmålet om prekære liv og vold og ikke-vold, og hvordan disse emner udspringer (...) af Butlers tænkning om køn i 1990’erne. /// In connection with Judith Butler's lecture on climate grief at KU, I have been asked to answer the question of how Butler's thinking could be used today and whether it is still relevant. My first thought was to answer the question with the answer: You can use Butler's thinking for EVERYTHING! However, to focus my answer, I have decided to review Butler's thinking in relation to the issues of precarious lives and violence and non-violence and how these issues stem from Butler's thinking on gender in the 1990s. (shrink)

This article is part of a For-Discussion-Section of Methods of Information in Medicine about the paper "Biomedical Informatics: We Are What We Publish", written by Peter L. Elkin, Steven H. Brown, and Graham Wright. It is introduced by an editorial. This article contains the combined commentaries invited to independently comment on the Elkin et al. paper. In subsequent issues the discussion can continue through letters to the editor.

There are two motivations commonly ascribed to historical actors for taking up statistics: to reduce complicated data to a mean value (e.g., Quetelet), and to take account of diversity (e.g., Galton). Different motivations will, it is assumed, lead to different methodological decisions in the practice of the statistical sciences. Karl Pearson and W. F. R. Weldon are generally seen as following directly in Galton’s footsteps. I argue for two related theses in light of this standard interpretation, based on a reading (...) of several sources in which Weldon, independently of Pearson, reflects on his own motivations. First, while Pearson does approach statistics from this "Galtonian" perspective, he is, consistent with his positivist philosophy of science, utilizing statistics to simplify the highly variable data of biology. Weldon, on the other hand, is brought to statistics by a rich empiricism and a desire to preserve the diversity of biological data. Secondly, we have here a counterexample to the claim that divergence in motivation will lead to a corresponding separation in methodology. Pearson and Weldon, despite embracing biometry for different reasons, settled on precisely the same set of statistical tools for the investigation of evolution. (shrink)

Os minerais possuem uma influência direta em diversos processos fisiológicos no organismo animal e, mesmo com tamanha importância, por vezes são negligenciados pelos produtores para seu fornecimento para os animais. Este estudo teve como objetivo avaliar o desempenho reprodutivo de rebanhos de bovinos, caprinos e ovinos em 8 propriedades rurais nas cidades de Sanharó, Pesqueira, Arcoverde, Belo Jardim e São Bento do Una através da adição de suplemento mineral e mistura múltipla aos animais de forma a atender suas necessidades básicas (...) para mantença e reprodução. Foram avaliados os desempenhos de 4 touros e 25 vacas, 3 bodes e 50 cabras e 4 carneiros e 48 ovelhas em diferentes propriedades, avaliando como a adição de um suplemento mineral específico da espécie impacta de forma positiva nos índices reprodutivos avaliados que foram taxa de cio, taxa de serviço, taxa de concepção, taxa de fertilidade, taxa de prenhez, taxa de perdas gestacionais, taxa de natalidade e taxa de mortalidade. O experimento teve duração de 2 anos e pôde-se avaliar cerca de 2 partos nas vacas e, mais ou menos, 3 partos em cabras e ovelhas. Os dados foram computados e avaliados estatisticamente no Excel para conferir se os índices reprodutivos melhoraram em função da adição de minerais na ração dos animais. Conferiu-se que houve diferença significativa entre todos os índices avaliados, ou seja, a adição de minerais na ração dos animais melhora a eficiência reprodutiva de machos e fêmeas de animais ruminantes, sendo de suma importância sua disponibilização de forma correta para alcançar bons índices reprodutivos na fazenda na busca pela obtenção de neonatos que poderão ser comercializados. -/- REFERÊNCIAS BIBLIOGRÁFICAS ASTRO, G. B. A importância da adição de minerais na dieta de caprinos e ovinos no Agreste de Pernambuco. Trabalho de Conclusão de Curso (Técnico Subsequente em Agropecuária) - IFPE Campus Belo Jardim. Belo Jardim, 2023. 44 p. BALAMURUGAN, B. et al. Mineral an important nutrient for efficient reproductive health in dairy cattle. Int. J. Environ. Sci. Technol, v. 6, n. 1, p. 694-701, 2017. Barros NN, Bomfim MAD. Mistura múltipla para caprinos e ovinos. In: Anais VIII PECNORDESTE – Seminário Nordestino de Pecuária, 8; 2004; Fortaleza, Brasil. Fortaleza: FAEC, 2004. p. 50-57. BERCHIELLI, T. T.; PIRES, A. V.; OLIVEIRA, S. G. (Eds.). Nutrição de ruminantes. Jaboticabal: Funep, 2011. COTTA, T. Minerais e vitaminas para bovinos, ovinos e caprinos. Viçosa: Aprenda Fácil, 2001. DANTAS, C. C. O.; DE MATTOS NEGRÃO, F. Funções e sintomas de deficiência dos minerais essenciais utilizados para suplementação dos bovinos de corte. UNICiências, v. 14, n. 2, 2010. DA SILVA EIC. A água na nutrição animal. 1ª ed. Recife, PE: Instituto Agronômico de Pernambuco, 2023. DA SILVA, Emanuel Isaque Cordeiro. Cálculos de consumo e digestibilidade de alimentos e nutrientes para ruminantes. Revista Universitária Brasileira, v. 1, n. 3, 2023. DA SILVA, Emanuel Isaque Cordeiro. Concentrados e Rações Para Cabras em Lactação. 2022. DA SILVA, Emanuel Isaque Cordeiro. Efeitos da raça e do manejo nutricional sobre as características de qualidade da carcaça e da carne em ovinos. Revista Universitária Brasileira, v. 2, n. 1, 2024. DA SILVA, Emanuel Isaque Cordeiro. Fisiologia da Reprodução de Bovinos Leiteiros: Aspectos Básicos e Clínicos. Emanuel Isaque Cordeiro da Silva, 2022. DA SILVA, Emanuel Isaque Cordeiro. Formulação de ração para caprinos. Emanuel Isaque Cordeiro da Silva, 2021. DA SILVA, Emanuel Isaque Cordeiro. Formulação de ração para ovinos. 2021. DA SILVA, Emanuel Isaque Cordeiro. Formulação e Avaliação de Suplemento Mineral Para Caprinos. Instrução Técnica Para o Produtor Rural de Pernambuco, v. 3, n. 1, p. 1-4, 2023. DA SILVA, Emanuel Isaque Cordeiro. Formulação e fabricação de rações para ruminantes. 1ª ed. Belo Jardim: Emanuel Isaque Cordeiro da Silva, 2021. DA SILVA, Emanuel Isaque Cordeiro. Formulação e Fabricação de Rações Para Ruminantes: Bovinos, Caprinos e Ovinos. 2021. DA SILVA, Emanuel Isaque Cordeiro. Manejo Reprodutivo e Índices Zootécnicos em Gado de Leite. 2023. DA SILVA, Emanuel Isaque Cordeiro. Métodos de Formulação e Balanceamento de Rações para Bovinos. Belo Jardim: Emanuel Isaque Cordeiro da Silva, 2021. DA SILVA, Emanuel Isaque Cordeiro. Nutrição e Suplementação Mineral de Bovinos de Corte. Emanuel Isaque Cordeiro da Silva, 2021. DA SILVA, Emanuel Isaque Cordeiro. Nutrição Sobre a Reprodução e Fertilidade dos Bovinos. Emanuel Isaque Cordeiro da Silva, 2021. DA SILVA, Emanuel Isaque Cordeiro. Opções de concentrados para vacas em lactação no Semiárido. 2022. DA SILVA, Emanuel Isaque Cordeiro. Relação e Efeitos Bioquímico-nutricionais Sobre os Cistos Ovarianos em Vacas. DA SILVA, Emanuel Isaque Cordeiro. Relação e Efeitos Bioquímico-nutricionais Sobre os Transtornos do Ciclo Estral em Vacas. DA SILVA, E. I. C. Suplementação e formulação de sal mineral e mistura múltipla para bovinos. Revista Universitária Brasileira, v. 2, n. 1, 2024. DE MENDONÇA JÚNIOR, A. F. et al. Minerais: importância de uso na dieta de ruminantes. Agropecuária Científica no Semiárido, v. 7, n. 1, p. 01-13, 2011. DE PAULA SILVEIRA, L. Suplementação mineral para bovinos. Medicina Veterinária e Zootecnia, v. 11, n. 5, p. 489-500, 2017. FADLALLA, I. M. T. The Interactions of Some Minerals Elements in Health and Reproductive Performance of Dairy Cows. New Advances in the Dairy Industry, 2022. FERGUSON, J. D. Nutrition and reproduction in dairy cows. Veterinary clinics of North America: Food animal practice, v. 7, n. 2, p. 483-507, 1991. GALVANI, D. B.; BOMFIM, MAD. Mistura múltipla para caprinos e ovinos: nova fórmula dispensa adaptação. 2015. HAENLEIN, G. F. W.; ANKE, M. Mineral and trace element research in goats: A review. Small Ruminant Research, v. 95, n. 1, p. 2-19, 2011. KAWAS, J. R.; ANDRADE-MONTEMAYOR, H.; LU, C. D. Strategic nutrient supplementation of free-ranging goats. Small Ruminant Research, v. 89, n. 2-3, p. 234-243, 2010. KESSLER, J. Mineral nutrition of goats. In: Goat nutrition, v. 46, p. 104-119, 1991. LOPES, H. O. S. Suplementação de baixo custo para bovinos: mineral e alimentar. 1998. MANERA, D. B. et al. Mineral mixtures from solid salt residues for lambs. Revista Brasileira de Zootecnia, v. 43, p. 485-491, 2014. MASTERS, D. G. Practical implications of mineral and vitamin imbalance in grazing sheep. Animal Production Science, v. 58, n. 8, p. 1438-1450, 2018. MORAES, S. da S. Importância da suplementação mineral para bovinos de corte. Campo Grande, MS: Embrapa Gado de Corte, 2001., 2001. NICODEMO, M. L. F. et al. Minerais na eficiência reprodutiva de bovinos. 1ª ed. São Carlos: Embrapa Pecuária Sudeste, 2008. 50 p. NIX, J.. Trace minerals important for goat reproduction. Sweetlix Livestock Supplement System, 2002. NOGUEIRA, É. et al. Nutrição aplicada à reprodução de bovinos de corte. In: MEDEIROS, S. R. et al. (Eds.). Nutrição de bovinos de corte: fundamentos e aplicações. 1ª ed. Brasília: Embrapa, 2015. p. 143-156. PASA, C.. Relação reprodução animal e os minerais. Biodiversidade, v. 9, n. 1, 2010. PEIXOTO, P. V. et al. Eficiência reprodutiva de matrizes bovinas de corte submetidas a três diferentes tipos de suplementação mineral. Pesquisa Veterinária Brasileira, v. 23, p. 125-130, 2003. PRADA, F. Influência da nutrição animal na reprodução de touros: revisão. Revista de Educação Continuada do CRMV-SP, v. 8, n. 1, p. 68-76, 2005. ROGÉRIO, M. C. P. et al. Manejo alimentar de caprinos e ovinos nos trópicos. Veterinária e Zootecnia, v. 23, n. 3, p. 326-346, 2016. SARTORI, R.; GUARDIEIRO, M. M. Fatores nutricionais associados à reprodução da fêmea bovina. Revista Brasileira de Zootecnia, v. 39, p. 422-432, 2010. SHARMA, M. C. et al. Mineral nutrition and reproductive performance of the dairy animals: a review. The Indian Journal of Animal Sciences, v. 77, n. 7, 2007. SILVA, D. C. et al. Importância do uso de minerais na dieta de bovinos reprodutores. Vet. zootec, p. 38-52, 2018. SOUZA, G. V. Suplementação de minerais na reprodução de bovinos. Trabalho de Conclusão de Curso (Graduação em Zootecnia) - UFG. Jataí, 2014. 32 p. TEIXEIRA, J. C. Nutrição de ruminantes. Lavras: FAEPE, 1992. UNDERWOOD, E. J.; SUTTLE, N. F. Los minerales en la nutrición del ganado. 3ª ed. Zaragoza: Acribia, 2003. VALADARES FILHO, S. C. et al. (Eds.). Tabelas brasileiras de composição de alimentos para ruminantes. 1ª ed. Viçosa: UFV, 2015. VALENTIM, J. K. et al. Fatores nutricionais aplicados à reprodução de ruminantes. UNICIÊNCIAS, v. 23, n. 2, p. 77-82, 2019. VASCONCELOS, F. F. Suplementação mineral no manejo reprodutivo ovino. Dissertação (Mestrado em Medicina Veterinária) - Centro de Ciências Rurais, UFSM. Santa Maria, 2012. 50 p. VÁZQUEZ-ARMIJO, J. F. et al. Trace elements in sheep and goats reproduction: a review. Tropical and Subtropical Agroecosystems, v. 14, n. 1, p. 1-13, 2011. VELLADURAI, C.; SELVARAJU, M.; NAPOLEAN, R. E. Effects of macro and micro minerals on reproduction in dairy cattle a review. International Journal of Scientific Research in Science and Technology, v. 2, n. 1, p. 68-70, 2016. YASOTHAI, R. Importance of minerals on reproduction in dairy cattle. International Journal of Science, Environment and Technology, v. 3, n. 6, p. 2051-2057, 2014. (shrink)

The book covers scientific and philosophical topics by bringing them closer to literature. Some topics are scientific explanation, the concept of cause, rational argumentation, pseudoscience, language, ethics, philosophy of mind, posthumanism, and democracy. Summary Prefazione di Severino Saccardi. Introduzione. Capitolo 1: Le scrivanie di Eddington. 1.1. Il vecchio Qfwfq (I. Calvino. Le cosmicomiche). 1.2. L’assassino invisibile (L.F. Celine, Il dottor Semmelweis). 1.3. Gli gnommeri di Ingravallo (C.E. Gadda, Quer pasticciaccio brutto de via Merulana). 1.4. I sergenti di Napoleone (L. Tolstoj, (...) Guerra e pace). 1.5. Tex e il Coyote nero (G. Bonelli, Il Coyote nero). 1.6. “Elementare Watson!” (A.C. Doyle, Il segno dei quattro). Capitolo 2. Non saranno mai delusi. 2.1. L’albero di Natale. (V. Perrin, Cambiare l’acqua ai fiori). 2.2. Il dagherrotipo di Buendia. (G.G. Marquez, Cent’anni di solitudine). 2.3. Don Ferrante e la peste. (A. Manzoni, I promessi sposi). Capitolo 3. Capitolo puffo. 3.1. L’Accademia di Lagado. (J. Swift, I viaggi di Gulliver). 3.2. Bruto è uomo d’onore. (W. Shakespeare, Giulio Cesare). 3.3. Le oche mute. (G. Orwell, 1984). Capitolo 4. “Quarantadue!” 4.1. Lo zio N’Ba N’Ga. (I. Calvino, Le cosmicomiche). 4.2. La mosca cocchiera. (J. de La Fontaine, Favole). 4.3. Il fiore del dr. Dek. (E. Salgari, Le meraviglie del Duemila). Capitolo 5. L’ultimo uomo. 5.1. La pernice accusatrice. (Cyrano de Bergerac, Gli stati e gli imperi del Sole). 5.2. Pallino in via Mjasnickaja. (M.A. Bulgakov, Cuore di cane). Capitolo 6. Scenari perturbanti. 6.1. Dissipatio. (G. Morselli, Dissipatio H.G.). 6.2. Un mammifero meccanizzato. (S. Butler, Erewhon). 6.3. Mlle Olimpia. (E.T.A. Hoffmann, Racconti notturni). Capitolo 7. La gente perbene. 7.1. La balena bianca. (H. Melville, Moby Dick). 7.2. Betsabea Everdeene. (T. Hardy, Via dalla pazza folla). 7.3. Un’idea francese. (C. McCarthy, Cavalli selvaggi). 7.4. Le montagne del Montana. (D. Delillo, Rumore bianco). (shrink)

740 page life in letters, including all Hegel's available letters at time of publication by Indiana University Press in 1984 tied together by a running commentary by Clark Butler. The volume is in a searchable PDF format. Publication was supported by a Major Grant by the National Endowment of the Humanities (NEH).

This thesis considers the following problem: What methods should the epistemology of science use to gain insight into the structure and behaviour of scientific knowledge and method in actual scientific practice? After arguing that the elucidation of epistemological and methodological phenomena in science requires a method that is rooted in formal methods, I consider two alternative methods for epistemology of science. One approach is the classical approaches of the syntactic and semantic views of theories. I show that typical approaches of (...) this sort are inadequate and inaccurate in their representation of scientific knowledge by showing how they fail to account for and misrepresent important epistemological structure and behaviour in science. The other method for epistemology of science I consider is modeled on the methods used to construct valid models of natural phenomena in applied mathematics. This new epistemological method is itself a modeling method that is developed through the detailed consideration of two main examples of theory application in science: double pendulum systems and the modeling of near-Earth objects to compute probability of future Earth impact. I show that not only does this new method accurately represent actual methods used to apply theories in applied mathematics, it also reveals interesting structural and behavioural patterns in the application process and gives insight into what underlies the stability of methods of application. I therefore conclude that for epistemology of science to develop fully as a scientific discipline it must use methods from applied mathematics, not only methods from pure mathematics and metamathematics as traditional formal epistemology of science has done. (shrink)

I present a reconstruction of F.H.C. Crick's two 1957 hypotheses "Sequence Hypothesis" and "Central Dogma" in terms of a contemporary philosophical theory of causation. Analyzing in particular the experimental evidence that Crick cited, I argue that these hypotheses can be understood as claims about the actual difference-making cause in protein synthesis. As these hypotheses are only true if restricted to certain nucleic acids in certain organisms, I then examine the concept of causal specificity and its potential to counter claims about (...) causal parity of DNA and other cellular components. I first show that causal specificity is a special kind of invariance under interventions, namely invariance of generalizations that range over finite sets of discrete variables. Then, I show that this notion allows the articulation of a middle ground in the debate over causal parity. (shrink)

Visual imagery is a form of sensory imagination, involving subjective experiences typically described as similar to perception, but which occur in the absence of corresponding external stimuli. We used the Activation Likelihood Estimation algorithm (ALE) to identify regions consistently activated by visual imagery across 40 neuroimaging studies, the first such meta-analysis. We also employed a recently developed multi-modal parcellation of the human brain to attribute stereotactic co-ordinates to one of 180 anatomical regions, the first time this approach has been combined (...) with the ALE algorithm. We identified a total 634 foci, based on measurements from 464 participants. Our overall comparison identified activation in the superior parietal lobule, particularly in the left hemisphere, consistent with the proposed ‘top-down’ role for this brain region in imagery. Inferior premotor areas and the inferior frontal sulcus were reliably activated, a finding consistent with the prominent semantic demands made by many visual imagery tasks. We observed bilateral activation in several areas associated with the integration of eye movements and visual information, including the supplementary and cingulate eye fields (SCEFs) and the frontal eye fields (FEFs), suggesting that enactive processes are important in visual imagery. V1 was typically activated during visual imagery, even when participants have their eyes closed, consistent with influential depictive theories of visual imagery. Temporal lobe activation was restricted to area PH and regions of the fusiform gyrus, adjacent to the fusiform face complex (FFC). These results provide a secure foundation for future work to characterise in greater detail the functional contributions of specific areas to visual imagery. (shrink)

El filósofo boliviano H. C. F. Mansilla estudió ciencias políticas y filosofía en universidades alemanas. La Freie Universität Berlin le concedió la venia legendi en 1976. Fue profesor visitante en universidades de Australia, Brasil, España y Suiza. Es miembro de número de la Academia Boliviana de Ciencias y de la Academia Boliviana de la Lengua y miembro correspondiente de la Real Academia Española y de la Academia Norteamericana de la Lengua Española. Autor de varios libros sobre ecología social y tradiciones (...) político-culturales latinoamericanas. H. C. F. Mansilla, en esta entrevista, nos expresó sus ideas sobre diversos temas de su trayectoria académica y sus reflexiones acerca de la responsabilidad del pensador en la sociedad boliviana. (shrink)

Een vrije en veerkrachtige samenleving ontstaat niet vanzelf en blijft niet vanzelf bestaan. In dit themanummer verkennen we de publieke onderwijstaak van het hoger beroepsonderwijs om studenten te onderwijzen de gemeenschappelijke wereld én het publieke gesprek over die wereld centraal te stellen. Met dit themanummer willen wij iets tegenover het vigerende marktdenken zetten. We laten ons hierbij inspireren door het gedachtegoed van Hannah Arendt (1906–1975). Ze heeft uitgebreid geschreven over ‘het publieke’. Ze verbindt de inzet van wetenschappelijke kennis en technologie (...) met het politieke vraagstuk: willen we daadwerkelijk leven in de wereld die we aan het scheppen zijn? Arendts gedachtegoed biedt volop handvatten om op verschillende niveaus van het hoger beroepsonderwijs deze taak te doordenken en invulling te geven. (shrink)

This paper explains how to use a new software tool for argument diagramming available free on the Internet, showing especially how it can be used in the classroom to enhance critical thinking in philosophy. The user loads a text file containing an argument into a box on the computer interface, and then creates an argument diagram by dragging lines from one node to another. A key feature is the support for argumentation schemes, common patterns of defeasible reasoning historically know as (...) topics . Several examples are presented, as well as the results of an experiment in using the system with students in a university classroom. (shrink)

Brain-related diseases are among the most difficult diseases due to their sensitivity, the difficulty of performing operations, and their high costs. In contrast, the operation is not necessary to succeed, as the results of the operation may be unsuccessful. One of the most common diseases that affect the brain is Alzheimer’s disease, which affects adults, a disease that leads to memory loss and forgetting information in varying degrees. According to the condition of each patient. For these reasons, it is important (...) to classify memory loss and to know the patient at what level and his assessment of Alzheimer's disease through CT scans of the brain. In this thesis, we review ways and techniques to use deep learning classification to classifying the Alzheimer's Disease The proposed method used to improve patient care, reduce costs, and allow fast and reliable analysis in large studies. The model will be designed using Python language for implementing the system, which is very useful for doctors, classifying the Alzheimer's Disease, was used. The model used 70% from image for training and 30% from image for validation, our trained model achieved an accuracy of 100% on a held-out test set. (shrink)

Background If trials of therapeutic interventions are to serve society's interests, they must be of high methodological quality and must satisfy moral commitments to human subjects. The authors set out to develop a clinical - trials compendium in which standards for the ethical treatment of human subjects are integrated with standards for research methods. Methods The authors rank-ordered the world's nations and chose the 31 with >700 active trials as of 24 July 2008. Governmental and other authoritative entities of the (...) 31 countries were searched, and 1004 English-language documents containing ethical and/or methodological standards for clinical trials were identified. The authors extracted standards from 144 of those: 50 designated as ‘core’, 39 addressing trials of invasive procedures and a 5% sample of the remainder. As the integrating framework for the standards we developed a coherent taxonomy encompassing all elements of a trial's stages. Findings Review of the 144 documents yielded nearly 15 000 discrete standards. After duplicates were removed, 5903 substantive standards remained, distributed in the taxonomy as follows: initiation, 1401 standards, 8 divisions; design, 1869 standards, 16 divisions; conduct, 1473 standards, 8 divisions; analysing and reporting results, 997 standards, four divisions; and post-trial standards, 168 standards, 5 divisions. Conclusions The overwhelming number of source documents and standards uncovered in this study was not anticipated beforehand and confirms the extraordinary complexity of the clinical trials enterprise. This taxonomy of multinational ethical and methodological standards may help trialists and overseers improve the quality of clinical trials, particularly given the globalisation of clinical research. (shrink)

Objective: To examine the current ethical review process of ethics committees in a non-pharmacological trial from the perspective of a clinical investigator.Design: Prospective collection of data at the Study Centre of the German Surgical Society on the duration, costs and administrative effort of the ERP of a randomised controlled multicentre surgical INSECT Trial between November 2003 and May 2005.Setting: Germany.Participants: 18 ethics committees, including the ethics committee handling the primary approval, responsible overall for 32 clinical sites throughout Germany. 8 ethics (...) committees were located at university medical schools and 10 at medical chambers. Duration was measured as days between submission and receipt of final approval, costs in euros and administrative effort by calculation of the product of the total number of different types of documents and the mean number of copies required .Results: The duration of the ERP ranged from 1 to 176 days. The median duration was 26 days at MSUs compared with 34 days at medical chambers. The total cost was €2947. 1 of 8 ethics committees at universities and 8 of 10 at medical chambers charged a median fee of €162 . The administrative effort for primary approval was 30. Four ethics committees required a higher administrative effort for secondary approval .Conclusion: The ERP for non-pharmacological multicentre trials in Germany needs improvement. The administrative process has to be standardised: the application forms and the number and content of the documents required should be identical or at least similar. The fees charged vary considerably and are obviously too high for committees located at medical chambers. However, the duration of the ERP was, with some exceptions, excellent. A centralised ethics committee in Germany for multicentre trials such as the INSECT Trial can simplify the ERP for clinical investigators in and outside the country. (shrink)

In fact, people get neck problems due to something such as sports or woke and Wrong sleep habits. In this paper an expert system was designed to help users to correctly diagnose neck problems world (muscle spasm, Muscle aches, Meningitis, herniated cervical disc, Fibromyalgia, Cervical spondylosis, Trigger points) with some information about the disease and self-care. Java language was used to design and implement this expert system.

There is no doubt that tomato diseases are one of the important reasons that destroy the tomato plant and its crops. This leads to clear damage to these plants and they become inedible. Discovering these diseases after a good step for proper and correct treatment. Determining the treatment with high accuracy depends on the method used in the diagnosis. Correctly, expert systems can greatly help to avoid damage to these plants. The expert system diagnoses tomato disease correctly to facilitate farmers (...) to find the correct treatment based on the appropriate diagnosis. Objectives: An expert system has been established based on CLIPS to diagnose tomato plant disease. (shrink)

Background: Obstetrics and gynaecology are many and common, where a woman suffers from problems related to pregnancy or her reproductive organs. Any part of her body may be affected due to some symptoms that are completely related to the reproductive organs when she is in a critical period for her, whether in her menstrual cycle, pregnancy, or disease conditions. The bulk of cases of diseases related to women and childbirth are dealt with great care and special care, as all diseases (...) related to women are considered very sensitive diseases due to the presence of the disease in sensitive and not simple places. A gynaecologist is a specialist in all diseases and problems related to the female sexual organs. They perform regular preventive medical exams, such as cervical smear tests and breast exams. It also provides consultations for women of all ages about the problems of contraception, infertility and menopause. Objectives: The objective of this expert system is to help and facilitate women in diagnosing diseases related to their obstetrics and gynaecology, a simple expert system has been designed consisting of ten various common diseases that affect women whether During or without pregnancy, Methods: In this system, the system consists of a list of some common symptoms, the correct diagnosis adopted for these diseases, and how to treat diseases in the correct way with the help of a consultant obstetrician and gynaecologist, Dr. Fathi Muhammad Al-Habibi, and these diseases are: uterine cancer, cervical cancer, Infertility, double uterus, ectopic pregnancy, endometrial cancer, female sexual dysfunction, endometriosis, faecal incontinence, female infertility, CLIPS Expert System language was used to design and implement the proposed expert system. Results: The proposed ten obstetrics and gynaecology diagnostic expert system was evaluated by medical students and they were satisfied with its performance. Conclusions: The proposed expert system is very useful for obstetricians and gynaecologists, patients with reproductive system problems, and recent graduates. (shrink)

Thе еxprоpriаtiоn оf аgriculturаl lаnd tо prоvidе nеw lаnd fоr industriаl аnd urbаn еxpаnsiоn, rеfеrrеd tо аs cоmpulsоry аcquisitiоn, is prеvаlеnt in dеvеlоping cоuntriеs. Using Viеtnаm аs а lаbоrаtоry, this study еvаluаtеs thе impаcts оf lоsing fаrmlаnd thrоugh cоmpulsоry аcquisitiоn оn hоusеhоld wеlfаrе аnd rеаchеs thе fоllоwing findings. A 10 pеrcеntаgе pоint incrеаsе in thе prоpоrtiоn оf lаnd еxprоpriаtеd rеsults in а 2.2% dеcrеаsе in hоusеhоld wеlfаrе prоxiеd by fооd еxpеnditurе. Bеsidеs, pоliticаlly uncоnnеctеd аnd еthnic minоrity hоusеhоlds аrе disprоpоrtiоnаtеly vulnеrаblе. (...) Thе аdvеrsе wеlfаrе еffеct cоuld tаkе up tо 10 yеаrs tо еvаpоrаtе. Thе rеductiоn in hоusеhоld wеlfаrе is аttributаblе tо thе dеclinе in аgriculturаl incоmе аnd thе inаbility tо pаrticipаtе in thе nоn-аgriculturаl lаbоr mаrkеt. Othеr аspеcts оf hоusеhоld bеhаviоr fоllоwing cоmpulsоry аcquisitiоn аrе аlsо еxplоrеd, such аs sаving, sоciаl cаpitаl, lаbоr, аnd cаpitаl аllоcаtiоn. (shrink)

Leuridan (2011) questions whether mechanisms can really replace laws at the heart of our thinking about science. In doing so, he enters a long-standing discussion about the relationship between the mech-anistic structures evident in the theories of contemporary biology and the laws of nature privileged especially in traditional empiricist traditions of the philosophy of science (see e.g. Wimsatt 1974; Bechtel and Abrahamsen 2005; Bogen 2005; Darden 2006; Glennan 1996; MDC 2000; Schaffner 1993; Tabery 2003; Weber 2005). In our view, Leuridan (...) misconstrues this discussion. His weak positive claim that mechanistic sciences appeal to generalizations is true but uninteresting. His stronger claim, that all causal claims require laws, is unsupported by his arguments. Though we proceed by criticizing Leuridan’s arguments, our greater purpose is to embellish his arguments in order to show how thinking about mechanisms enriches and transforms old philosophical debates about laws in biology and provides new insights into how generalizations afford prediction, explanation and control. (shrink)

Thе еxprоpriаtiоn оf аgriculturаl lаnd tо prоvidе nеw lаnd fоr industriаl аnd urbаn еxpаnsiоn, rеfеrrеd tо аs cоmpulsоry аcquisitiоn, is prеvаlеnt in dеvеlоping cоuntriеs. Using Viеtnаm аs а lаbоrаtоry, this study еvаluаtеs thе impаcts оf lоsing fаrmlаnd thrоugh cоmpulsоry аcquisitiоn оn hоusеhоld wеlfаrе аnd rеаchеs thе fоllоwing findings. A 10 pеrcеntаgе pоint incrеаsе in thе prоpоrtiоn оf lаnd еxprоpriаtеd rеsults in а 2.2% dеcrеаsе in hоusеhоld wеlfаrе prоxiеd by fооd еxpеnditurе. Bеsidеs, pоliticаlly uncоnnеctеd аnd еthnic minоrity hоusеhоlds аrе disprоpоrtiоnаtеly vulnеrаblе. (...) Thе аdvеrsе wеlfаrе еffеct cоuld tаkе up tо 10 yеаrs tо еvаpоrаtе. Thе rеductiоn in hоusеhоld wеlfаrе is аttributаblе tо thе dеclinе in аgriculturаl incоmе аnd thе inаbility tо pаrticipаtе in thе nоn-аgriculturаl lаbоr mаrkеt. Othеr аspеcts оf hоusеhоld bеhаviоr fоllоwing cоmpulsоry аcquisitiоn аrе аlsо еxplоrеd, such аs sаving, sоciаl cаpitаl, lаbоr, аnd cаpitаl аllоcаtiоn. (shrink)

The global water crisis is being exacerbated by climate change, even in the United States. Recycled water is a feasible alternative to alleviate the water shortage, but it is constrained by humans’ perceptions. The current study examines how residents’ water scarcity awareness and climate change belief influence their willingness to use recycled water directly and indirectly. Bayesian Mindsponge Framework (BMF) analytics was employed on a dataset of 1831 residents in Albuquerque, New Mexico, an arid inland region in the US. We (...) discovered that residents’ willingness to use direct recycled potable water is positively affected by their awareness of water scarcity, but only if they believe in the impacts of climate change on the water cycle. Meanwhile, the willingness to use indirect recycled potable water is influenced by water scarcity awareness, and the belief in climate change further enhances this effect. These findings implicate that fighting climate change denialism and informing the public of the water scarcity situation in the region can contribute to the effectiveness and sustainability of long-term water conservation and climate change alleviation efforts. (shrink)

Abstract: This paper endeavors to establish a comprehensive account of human knowledge that embraces the probabilistic nature of truth, the integral role of language in our cognitive processes, and the uncertainty and fallibility inherent in our cognitive systems. Drawing upon the work of various philosophers, psychologists, and neuroscientists, the paper advocates for a reinterpretation of the traditional "Justified True Belief" as "Justified Probable Belief." Additionally, the biological underpinnings of this perspective are explored, with an emphasis on synaptic plasticity, dopamine-based learning, (...) and epigenetic mechanisms. (shrink)

In accordance with Leo Strauss’s ingenious suggestion, the Athenian Stranger of Plato’s Laws is best understood as an alternative ‘Socrates’, fleeing from the hemlock to Crete. Situated between Crito and Phaedo, Laws effectively tests the reader’s loyalty to the real Socrates who obeys Athenian law and dies cheerfully in Athens. Having separated Plato from the Stranger, a nuanced defence of Karl Popper’s suspicions about Laws confronts the apologetic readings of both Strauss and Christopher Bobonich. As hinted by his preference for (...) wine, the antidote for hemlock, the Athenian Stranger repeatedly proves himself the opposite of Socrates, particularly with respect to piety. Once the Stranger is recognized as ‘an unreliable narrator’, this apparently ponderous product of Plato’s senility becomes the taut thriller of an innovative teacher at the peak of his powers. (shrink)

A pineapple is a tropical plant with eatable leafy foods most monetarily critical plant in the family Bromeliaceous. The pineapple is native to South America, where it has been developed for a long time. The acquaintance of the pineapple with Europe in the seventeenth century made it a critical social symbol of extravagance. Since the 1820s, pineapple has been industrially filled in nurseries and numerous tropical manors. Further, it is the third most significant tropical natural product in world creation. In (...) the twentieth century, Hawaii was a prevailing maker of pineapples, particularly for the US, be that as it may, by 2016, Costa Rica, Brazil, and the Philippines represented almost 33% of the world's creation of pineapples. In this paper, machine learning based approach is presented for identifying type pineapple with a dataset that contains 1,311images use 946 images for training, 197 images for validation and 168 images for testing. A deep learning technique that extensively applied to image recognition was used. use 70% from image for training and 30% from image for validation. Our trained model achieved an accuracy of 100% on a heldout test set. (shrink)

While several tests and strategies are recommended for colorectal cancer (CRC) screening, studies suggest that primary care providers often recommend colonoscopy without providing information about its risks or alternatives. These observations raise concerns about the quality of informed consent for screening colonoscopy.

Environmental philosophy – broadly conceived as using philosophical tools to develop ideas related to environmental issues – is conducted and practised in highly diverse ways in different contexts and traditions in Asia. ‘Asian environmental philosophy’ can be understood to include Asian traditions of thought as well as grassroots perspectives on environmental issues in Asia. Environmental issues have sensitive political facets tied to who has the legitimacy to decide about how natural resources are used. Because of this, the works, practices, and (...) researchers in Asian environmental philosophy are exposed to being (mis)used by diverse stakeholders and actors to support political ends not related to environmental sustainability. Two processes are at play at the nexus of the construction of identities in relation to conceptualisations of nature: eco-orientalism and ecological nationalisms. This paper analyzes and exemplifies these dynamics through a conceptual framework that distinguishes ideological and socio-technical explanations of environmental degradation. Finally, to minimise the risks of political misuse, five pathways are presented to carefully help curate environmental, philosophical statements: contextualise, quantify uncertainty and ‘uniqueness’, downscale, confront claims with local realities and literature, and collaborate with researchers from other disciplines. Conjointly, these pathways aim at favouring intercultural collaboration while valuing diversity, thus supporting the development and exchanges in environmental philosophy in Asia and beyond. (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

Resumo A transferência de embriões em bovinos tem o objetivo principal de aprimorar o melhoramento genético e otimizar a reprodução bovina A importância dessa prática é destacada pela sua contribuição para a maximização de características desejadas nos rebanhos, como qualidade de carne, eficiência reprodutiva e resistência a condições ambientais adversas. Este trabalho descreve e analisa as técnicas avançadas utilizadas nesse processo, incluindo seleção genômica, sexagem de embriões, produção in vitro, protocolos não cirúrgicos, sincronização reprodutiva, criopreservação de embriões e uso de (...) marcadores de fertilidade. A compreensão aprofundada dessas técnicas é fundamental para o sucesso da transferência de embriões, bem como para a capacidade de personalizar e aprimorar as características específicas dos rebanhos. Enfatizando a importância da expertise de profissionais especializados em reprodução bovina, este trabalho busca oferecer uma visão abrangente das práticas atuais e avanços tecnológicos nesse campo. Ao unir ciência e prática, torna-se importante a comparação de técnicas, bem como relacionar resultados eficientes para promover qualidade genética, trazer a sustentabilidade e envolver a técnica em um cenário atualizado da indústria. Palavras-chave: Embriões; Hormônio; Reprodutor. -/- Abstract Embryo transfer into cattle has the main objective of improving genetic improvement and optimizing bovine reproduction. The importance of this practice is highlighted by its contribution to maximizing desired characteristics in herds, such as meat quality, reproductive efficiency and resistance to environmental conditions adverse. This work describes and analyzes the advanced techniques used in this process, including genomic selection, embryo sexing, in vitro production, non-surgical protocols, reproductive synchronization, embryo cryopreservation and the use of fertility markers. An in-depth understanding of these techniques is critical to the success of embryo transfer, as well as the ability to customize and enhance specific herd characteristics. Emphasizing the importance of the expertise of professionals specialized in bovine reproduction, this work seeks to offer a comprehensive view of current practices and technological advances in this field. When combining science and practice, it becomes important to compare techniques, as well as relate efficient results to promote genetic quality, bring sustainability and involve the technique in an updated industry scenario. Keywords: Embryos; Hormone; Reproducer. -/- REFERÊNCIAS BIBLIOGRÁFICAS ABIEC. Associação Brasileira das Indústrias Exportadoras de Carnes. Beef Report. Perfil da Pecuária no Brasil. v.6, p. 7, 2021. ALVAREZ, R. Transfer of blastocysts derived short-term in culture of quality morulae in vivo. Domestic Animals. v.9, p. 790, 2007. ALVES, N. G. Atividade Ovariana em Fêmeas Bovinas da Raça Holandesa e Mestiças Holandês x Zebu, Durante Dois Ciclos Estrais Normais Consecutivos. Revista Zootecnia. v.7, p. 86, 2002. ANDRADE, J. Use of hormone treatments to superovulation Nelore donors. Reproduction Science. v.9, p. 70, 2002. Associação Brasileira de Inseminação Artificial (ASBIA). Index Asbia 2021. v.7, p. 6, 2021. Associação Brasileira de Inseminação Artificial (ASBIA). Index ASBIA Mercado, v.8, p. 6, 2019. BARROS, C. M. Tratamentos superestimulatórios utilizados em protocolos para a transferência de embriões bovinos. Acta Scientiae Veterinariae. v.9, p.8, 2007. BARUSELLI, P. S. Avaliação do mercado de IATF no Brasil. Boletim Eletrônico do Departamento de Reprodução Animal – FMVZ/USP, 1. ed., v.8, p.7, 2019. BARUSELLI, P. S.; CATUSSI, B. L. C.; ABREU, L. A.; ELLIFF, F. M.; SILVA, L. G.; BATISTA, E. S.; CREPALDI, G. A. Evolução e perspectivas da Inseminação Artificial em bovinos. Revista Brasileira de Reprodução Animal, v.43, n.2, p.308-314, 2019. 13 BARUSELLI, P. S. IATF gera ganhos que superam R$ 3,5 bilhões nas cadeias de produção de carne e de leite. Boletim Eletrônico do Departamento de Reprodução Animal/FMVZ/USP, 2.ed., v.8, n.8, p.7, 2019. BINELLI, M. Anti-luteolytic to improve in cattle. Acta Scientiae Veterinariae. v.9, p.8, 2001. BÓ, G. A. Manipulação hormonal do ciclo estral em doadoras e receptoras de embrião bovino. Acta Scientiae Veterinariae. v.9, p.7, 2004. BÓ, G.; MAPLETOFT, R. Evaluation and of bovine. Animal Reproduction. v.8, p.9, 2013. BUSS, V. Efeito da dose e momento da administração de eCG em protocolos de IATF aplicados e vacas de corte em anestro. Universidade Federal do Pampa, Dissertação – Programa de Pós-Graduação em Ciência Animal, v.8, n.8, p.9, 2020. Centro de Estudos Avançados em Economia Aplicada (CEPEA). Boletim do leite. São Paulo, Ano 25, n.286, 2019. CHAVES, D. F.; ALVES, M. J. Protocolo de receptoras de embriões: índices de aproveitamento de corpo lúteo e taxa de prenhez. Animal Reproduction. v.9, p.7, 2023. DA SILVA, Emanuel Isaque Cordeiro. Fisiologia Clínica do Ciclo Estral de Vacas Leiteiras: Desenvolvimento Folicular, Corpo Lúteo e Etapas do Estro. 2020. DA SILVA, Emanuel Isaque Cordeiro. Transferência de Embriões nos Animais e a Indústria de Embriões no Brasil. 2020. DALCIN, L.; LUCCI, C. M. Criopreservação de embriões de animais de produção: princípios criobiológicos e estado atual. Rev. Bras. Reprod. Anim. v.7, p.7, 2010. DANTAS, K. S. A. Seleção de receptoras em um programa de transferência de embriões (PIVE) em bovinos no nordeste do Brasil. Ciência Animal. v.9, p.7, 2018. D’AVILA, C. A.; MORAES, F. P.; LUCIA J. R. T.; GASPERIN, B. G. Hormônios utilizados na indução da ovulação em bovinos – Artigo de revisão. Revista Brasileira de Reprodução Animal, v.43, n.4, p.797-802, 2019. DEMÉTRIO, D. G. B. Colheita e transferência de embriões bovinos. Dissertação (Mestrado em Reprodução Animal) – Faculdade de Medicina Veterinária e Zootecnia da UNESP, Campus de Botucatu, São Paulo. v.9, p.76, 2003. FAO – Organização das Nações Unidas para a Alimentação e Agricultura. O Estado da Insegurança Alimentar e Nutrição no Mundo (SOFI) 2021. Faculdade de Medicina Veterinária e Zootecnia da UNESP. v.4, n.6, p.6, 2021. FILHO, L. C. C. Fatores que interferem na eficiência reprodutiva de receptoras de embrião bovino. Arq. Ciênc. Vet. Zool. v.7, p.9, 2013. GONZÁLEZ, F. H. D. Introdução a Endocrinologia Reprodutiva Veterinária. UFRGS. v.9, p.7, 2002. GOODHAND, K. In vivo recovery and vitro embryo from bovine aspirated at frequencies or FSH treatment. Animal Reproduction. v.8, p.87, 1999. 14 HAFEZ, E. S. E.; HAFEZ, B. Reprodução animal. 7ed. Barueri: Manole. v.7, p.7, 2004. HONORATO, M.T. Importância da escolha de receptoras em um programa de transferência de embriões em bovinos. Barueri: Manole. v.8, p.6, 2013. HOPPER, R. Bovine Reproduction. Blackwell. v.8, p.8, 2015. IBGE. Instituto Brasileiro de Geografia e Estatística. Pesquisa da Pecuária Municipal 2021 (PPM 2021). IBGE. v.9, n.7, p.7, 2021. KONIG, H. E.; LIEBICH, H. G. Anatomia dos animais domésticos: texto e atlas colorido. Vol.2. Porto Alegre: Artmed, v.2, p.4, 2004. MARTINS, F. S. Fatores reguladores da foliculogênese em mamíferos. Rev Bras Reprod Anim. v.3, p.9, 2008. MELLO, R. R. C. Desenvolvimento folicular inicial em bovinos. Rev. Bras. Reprod. Anim. v.8, p.9, 2013. OLIVEIRA, A. F. M. Principais hormônios que controlam o comportamento reprodutivo e social das fêmeas ruminantes – Revisão. Rev. Bras. Reprod. v.9, p.8, 2014. OLIVEIRA, C. S. Biotécnicas da Reprodução em Bovinos. EMBRAPA, v.8, p.8, 2014. PASA, C. Transferência de embriões em bovinos. Biodiversidade. v.9, p.9, 2008. PENITENTE FILHO, J. M. Produção de embriões bovinos in vivo e in vitro. Revista CFMV, Ano XX. v.8, p.8, 2014. PHILLIPS, P. E.; JAHNKE, M. M. Embryo Transfer (Techniques, Dono rs, and Recipients). Vet Clin Food Anim, v.9, p.8, 2016. RODRIGUES, J.; BERTOLINI, M. Biotecnologias da reprodução animal: de Aristóteles à edição gênica. Rev. Bras. Reprod. Anim. v.8, p.7, 2019. SANTOS, K. J. G. Biotecnologias reprodutivas e fisiologia reprodutiva da fêmea bovina – conhecimento para o sucesso. Rev. Bras. Reprod. Anim. v.8, p.98. 2012. SANTOS, P. H. Impactos da superestimulação ovariana sobre a diferenciação das células da granulosa bovina. Dissertação de Mestrado em Farmacologia e Biotecnologia – UNESP, v.8, p.8. 2017. SILVA, P. R. B. Regulação farmacológica do ciclo estral de bovinos. UNESP. v.9, p.8. 2011. (shrink)

Sheep production is the most representative livestock activities in Brazil and in the world. However, the reproductive performance of these animals is determined by factors genetic, physical environment, management and, especially, nutritional. Thirty half-breed lambs from Dorper × Santa Inês were used, with initial weight and age of 31.87 ± 0.5 kg and 157 days, respectively. These animals were prepared on a diet with three food levels (ad libitum, 30% and 70%). Morphometric measurements were measured at intervals of 16 to (...) 20 days in 56 experimental days. The measurements performed were scrotal circumference (CE), chest circumference (CT), body condition score (ECC), withers height (AC) and scrotal bag thickness (EBE), body weight (CP) and semen collection. Interaction occurrence for biometric measurements between food levels and age (p <0.05). The TC and ECC values were higher in animals fed ad libitum (p <0.001). EBE had higher values in animals ad libitum and at 211 days of age (p <0.001). The CP was increasing for the animals ad libitum and (p <0.05) throughout the experiment, while the T30 was only in the initial period. T70 animals did not grow during the whole experiment. CE was influenced by diet (p <0.001) and age (p <0.001) independently. So that animals under food restriction had less development and was higher in older animals. The AC values were influenced only by age (p <0.001), demonstrating the effect of age growth. We conclude that it is not advantageous to submit lambs, it corrects food reproduction. Although it was not possible to assess whether initial malnutrition would bring future problems for the animal's seminal quality, it proved to be immensely negative for the onset of puberty and the development of reproductive structures. -/- REFERÊNCIAS BIBLIOGRÁFICAS AKUMBUGU, F. E., et al. Correlation between Body and Testicular Biometric Characteristics of West African Dwarf Rams. Multidisciplinary Advances in Veterinary Science. 2.4, 2018 ALLAOUI, A. et al. Factors affecting scrotal measurements and weight of Ouled Djellal rams in Eastern and South-eastern Algeria. APCBEE procedia, v. 8, p. 260-265, 2014. ALVES, J. M. et al. Estação de nascimento e puberdade em cordeiros Santa Inês. Revista Brasileira de Zootecnia, v. 35, n. 3, p. 958-966, 2006. ALVES, K. S. et al. Níveis de energia em dietas para ovinos Santa Inês: características de carcaça e constituintes corporais. Revista Brasileira de Zootecnia, v. 32, n. 6, p. 1927-1936, 2003. BIELLI, A. et al. Low maternal nutrition during pregnancy reduces the number of Sertoli cells in the newborn lamb. Reproduction, Fertility and Development, v. 14, n. 6, p. 333-337, 2002. BROWN, D. C.; STIRLING, H. F.; KELNAR, C. J. H. Precocious puberty. Paediatrics and Child Health, v. 4, n. 3, p. 184-188, 1994. BUDAI, C. Performance and adaptability of the Dorper sheep breed under Hungarian and Romanian rearing conditions. Scientific Papers Animal Science and Biotechnologies, v. 46, n. 1, p. 344-349, 2013. CARNEIRO, P. L. S. et al. Desenvolvimento ponderal e diversidade fenotípica entre cruzamentos de ovinos Dorper com raças locais. Pesquisa Agropecuária Brasileira, v. 42, n. 7, p. 991-998, 2007. CARRIJO JUNIOR, O. A. et al. Morphological evaluation of the testicles of young santa Inês rams submitted to different regimes of protein supplementation and drenching. Ciência animal brasileira, Goiânia, v. 9, n. 2, p. 433-441, abr./jun. 2008. CASTRO, F.A.B. de et al. Desempenho de cordeiros Santa Inês do nascimento ao desmame filhos de ovelhas alimentadas com diferentes níveis de energia. Semina: Ciências Agrárias, v. 33, n. 6 supl 2, p. 3379-3388, 2012 CEZAR, M. F. et al. 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Despite pervasive variation in the content of laws, legal theorists and anthropologists have argued that laws share certain abstract features and even speculated that law may be a human universal. In the present report, we evaluate this thesis through an experiment administered in 11 different countries. Are there cross‐cultural principles of law? In a between‐subjects design, participants (N = 3,054) were asked whether there could be laws that violate certain procedural principles (e.g., laws applied retrospectively or unintelligible laws), and also (...) whether there are any such laws. Confirming our preregistered prediction, people reported that such laws cannot exist, but also (paradoxically) that there are such laws. These results document cross‐culturally and –linguistically robust beliefs about the concept of law which defy people's grasp of how legal systems function in practice. (shrink)

Many countries are experiencing increasing levels of demand for access to assisted reproductive technologies. Policies regarding who can access ART and with what support from a collective purse are highly contested, raising questions about what state responses are justified. Whilst much of this debate has focused on the status of infertility as a disease, we argue that this is something of a distraction, since disease framing does not provide the far-reaching, robust justification for state support that proponents of ART seem (...) to suppose. Instead, we propose that debates about appropriate state responses should consider the various implications for health and broader well-being that may be associated with difficulties starting a family. We argue that the harms and disruption to valued life projects of subfertility-related suffering may provide a stronger basis for justifying state support in this context. Further, we suggest that, whilst ART may alleviate some of the harm resulting from subfertility, population-level considerations can indicate a broader range of interventions aimed at tackling different sources of subfertility-related harm, consistent with broader public health aims. (shrink)

In celebration of Newton da Costa’s place in the history of paraconsistency, this paper considers the use and abuse of deliberate self-contradiction. Beginning with Parmenides, developed by Plato, and continued by Cicero, an ancient philosophical tradition used deliberately paraconsistent discourses to reveal the truth. In modern times, decisionism has used deliberate self-contradiction against Judeo-Christian revelation. • DOI:10.5007/1808-1711.2010v14n1p1.

In discussing whether legal systems are necessarily coercive, legal philosophers usually appeal to thought experiments involving angels or other morally driven beings who need no coercion to organise their social lives. Such appeals have invited criticism. Critics have not only challenged the relevance of such thought experiments to our understanding of legal systems; they have also argued that, contrary to the intuitions of most legal philosophers, the ‘man on the Clapham Omnibus’ would not hold that there is law in a (...) society of angels because the view that law is necessarily coercive ‘enjoys widespread support among laypersons’. This is obviously an empirical claim. Critics, however, never systematically polled the ‘man on the Clapham Omnibus’. We boarded that bus. This article discusses findings from five empirical studies on the relationship between law and coercion. (shrink)

Mindfulness training has been used to improve emotional wellbeing in early adolescents. However, little is known about treatment outcome moderators, or individual differences that may differentially impact responses to treatment. The current study focused on gender as a potential moderator for affective outcomes in response to school-based mindfulness training. Sixth grade students (N = 100) were randomly assigned to either the six weeks of mindfulness meditation or the active control group as part of a history class curriculum. Participants in the (...) mindfulness meditation group completed short mindfulness meditation sessions four to five times per week, in addition to didactic instruction (Asian history). The control group received matched experiential activity in addition to didactic instruction (African history) from the same teacher with no meditation component. Self-reported measures of emotional wellbeing/affect, mindfulness, and self-compassion were obtained at pre and post intervention. Meditators reported greater improvement in emotional wellbeing compared to those in the control group. Importantly, gender differences were detected, such that female meditators reported greater increases in positive affect compared to females in the control group, whereas male meditators and control males displayed equivalent gains. Uniquely among females but not males, increases in self-reported self-compassion were associated with improvements in affect. These findings support the efficacy of school-based mindfulness interventions, and interventions tailored to accommodate distinct developmental needs of female and male adolescents. (shrink)

How does microbiota research impact our understanding of biological individuality? We summarize the interdisciplinary summer school on "Microbiota, Symbiosis and Individuality: Conceptual and Philosophical Issues" (July 2019), which was supported by a European Research Council starting grant project "Immunity, DEvelopment, and the Microbiota" (IDEM). The summer school centered around interdisciplinary group work on four facets of microbiota research: holobionts, individuality, causation, and human health. The conceptual discussion of cutting-edge empirical research provided new insights into microbiota and highlights the value of (...) incorporating into meetings experts from other disciplines, such as philosophy and history of science. (shrink)

This essay seeks to acknowledge the unsettling reality of children being intentionally maimed towards disability and disfigurement as economic commodity. The issue is easily invisibilized in modern education, and understandably so: the trauma triggered by these bloody realities can automatically disqualify the content for formal in school education as a form of “unwelcome truth”. Freire and Fanon, however, did not shy away from the horrific state of life for the oppressed and the wretched in their consideration of pedagogy. The lived (...) experience of maimed children is tragic, but it is lived experience nonetheless – acknowledged by hooks as “a way of knowing that coexists in a non-hierarchical way with other ways of knowing” (2014). In other words, this knowledge exists but is arguably not mobilized by society towards action. Critical consciousness, upheld by Freire as the key to seeing inequality to act upon it, is a goal beyond reach for the maimed children themselves. Here, we consider the extension proposed by Nicholls (2011), who discusses pedagogy of the privileged as an equally important parallel towards collaborative action against long-standing inequalities. In the context of these children having minimal access to education, we contend that privileged students must be the ones to carry forth the knowledge towards their own critical consciousness. Specifically, we explore what acknowledging children who are maimed could offer towards pedagogy, in relation to helping students to 1) minimize the act of “othering” in a global community; 2) reconsider the role of mass-media and media literacy in their critical consciousness; and 3) move away from surface-level, performative charity against societal inequalities. (shrink)

Tarixi biliklər məcmusu olan- idrak və onun istiqamətləri, insan hissləri, qavrayış, təsəvvür və onların müasir ictimai həyatdakı əksinin tədqiqi, həm də “müsəlman idrakı” anlayışı İslam fəlsəfəsində xüsusi mövqeyə malikdir. Müxtəlif alimlər ət-Tirmizi, Əbu Əbdullah əl-Haris, Əbu Əbdullah əl-Qurtubi, ibn Həcər əl-Əsqalani və başqalarının bu mövzuda xüsusi yanaşması olmuşdur. Bu məsələ ilə əlaqədar olan “mötəzililər”, “ismailililər”, “mistisistlər” (sufilər), “işraqilər”, həmçinin Şərq peripatetizminin ardıcılları varlıq, bilik təlimləri, “nəfs və qəlbin ölməzliyi” və idrakın əsas elementi olan təcrübə haqqında qiymətli fikir xəzinələri qoymuşlar. Bu (...) da müasir tədrisdə vacib yer tutur. Məqalədə “İdrak fəlsəfəsi” anlayışına nəzər salınmış, onun yaranması, əhəmiyyəti, canlı və cansız təbiətdəki əksi, istiqamətləri və fərqliliyi ilə əlaqədar fikirlər şərh edilmiş, müasir islamşünaslıqda bu anlayışın tədrisində istinad ediləcək məqamlara diqqət yetirilmişdir. Bu məqsədlə araşdırmada “İdrak- beyin xüsusiyyətidir”, “Cansız təbiətdə idrakın əksi”, “Canlı təbiətdə idrakın təzahürü”, “Dərk necə yaranıb?”, “İdrakın mahiyyəti nədir?”, “İdrakın istiqamətləri”, “İdrak dəyişkənliyi” və digər suallara Şərq-Qərq fəlsəfi görüşlərinə əsasən nəzər salınaraq qeyd edilən problemin həllinə cəhd edilmişdir. Zənginliyi və müxtəlifliyi ilə seçilən İslam fəlsəfəsində dini idrak ilə birgə həm də dünyəvi və real düşüncə mövcud olmuşdur. Bu axın yeni dövrün tələbi ilə müəyyən dəyişikliyə uğramış və nəinki Şərq, həm də dünyaya öz təsirini göstərmişdir. (shrink)

Abstract: The incorporation of Artificial Intelligence (AI) into educational technology has dramatically transformed learning through Intelligent Tutoring Systems (ITS). These systems utilize AI to offer personalized, adaptive instruction tailored to each student's needs, thereby improving learning outcomes and engagement. This paper examines the development and impact of ITS, focusing on AI technologies such as machine learning, natural language processing, and adaptive algorithms that drive their functionality. Through various case studies and applications, it illustrates how ITS have revolutionized traditional educational methods (...) and addresses the challenges and limitations, including data privacy and system biases. The discussion also covers future directions in ITS development, highlighting emerging trends and potential advancements. The goal is to provide a thorough understanding of how ITS use AI to enhance educational experiences and suggest avenues for future research in this evolving field. (shrink)

Three separate churches erected in Constantinople were all dedicated to the wisdom of Christ and erected on the same site one after the other. These churches were built between 360 and 537 AD by three different emperors: Constantius II, Theodosius the Younger, and Justinian I. The first two churches were consumed in flames after relatively short lives, but the final and greatest church still stands today, despite a history of extensive damage. This final edifice is the main focus of this (...) paper, owing to its 1500 year longevity and unprecedented architecture. If the entire History of Justinian's church is to considered, it is inaccurate to refer to it as a “church,” because although it remained a church for the first 900 years after its audacious construction, it was later converted into a mosque. Today it is a museum, in remembrance of its long history. (24). (shrink)

Background: There is no doubt that strawberry diseases are one of the most important reasons that led to the destruction of strawberry plants and their crops. This leads to obvious damage to these plants and they become inedible. Discovering these diseases after a good step for proper and correct treatment. Determining the treatment with high accuracy depends on the method used in the diagnosis. Correctly, expert systems can greatly help in avoiding damage to these plants. The expert system correctly diagnoses (...) strawberry disease to make it easier for farmers to find the right treatment based on the appropriate diagnosis. Objectives: The main goal of this expert system is to get the appropriate diagnosis of disease and the correct treatment. Methods: In this paper the design of the proposed Expert System which was produced to help Farmers and students interested in agriculture strawberry in diagnosing many of the strawberry diseases such as: Leaf Spots, Grey Mold, Red Stele/Red Core, Wilt, Powdery Mildew, Alternaria Spot, Black Root Rot, Anthracnose (black spot), and Angular Leaf Spot. The proposed expert system presents an overview about strawberry diseases are given, the cause of diseases are outlined and the treatment of disease whenever possible is given out. CLIPS language was used for designing and implementing the proposed expert system. Results: The proposed strawberry diseases diagnosis expert system was evaluated by Farmers and they were satisfied with its performance. Conclusions: The Proposed expert system is very useful for Farmers with strawberry problem and students interested in agriculture strawberry. (shrink)

Upshot: In our response we focus on five questions that point to important common themes in the commentaries: why start in wicked problems, what kind of system is a scientific perspective, what is the nature of second-order research processes, what does this mean for understanding interdisciplinary work, and how may polyocular research help make real-world decisions.

The current study is a pilot trial to examine the effects of a nonelective, classroom-based, teacher-implemented, mindfulness meditation intervention on standard clinical measures of mental health and affect in middle school children. A total of 101 healthy sixth-grade students (55 boys, 46 girls) were randomized to either an Asian history course with daily mindfulness meditation practice (intervention group) or an African history course with a matched experiential activity (active control group). Self-reported measures included the Youth Self Report (YSR), a modified (...) Spielberger State-Trait Anxiety Inventory, and the Cognitive and Affective Mindfulness Measure –Revised. Both groups decreased significantly on clinical syndrome subscales and affect but did not differ in the extent of their improvements. Meditators were significantly less likely to develop suicidal ideation or thoughts of self-harm than controls. These results suggest that mindfulness training may yield both unique and non-specific benefits that are shared by other novel activities. (shrink)